REAL-WORLD RESEARCH IN ACTION
See the World through Project IRIS
In situ Registry of Insights and Stories
Project IRIS: In situ Registry of Insights and Stories
Capturing Psychedelic Experiences Outside of Regulated Spaces
Unlimited Sciences is launching Project IRIS: a landmark longitudinal study focused entirely on capturing the real-world trajectories, context, outcomes, and experiences of non-facilitated use (NFU) of psychedelics.
Need to brush up on your Latin? In situ translates to "in its original place," which in the world of research means studying a phenomenon in its natural setting. While clinical trials observe psychedelics in a lab, Project IRIS meets the medicine where it actually lives: in the real world, among the community, and in the hands of the people.
This project is essential because:
Need to brush up on your Latin? In situ translates to "in its original place," which in the world of research means studying a phenomenon in its natural setting. While clinical trials observe psychedelics in a lab, Project IRIS meets the medicine where it actually lives: in the real world, among the community, and in the hands of the people.
This project is essential because:
- NFU is the majority: Most psychedelic use occurs outside of licensed clinical settings.
- Policy needs data: Critical public health and policy decisions lack data on NFU safety and outcomes.
- A holistic view is needed: We're aligning our data collection with other leaders in psychedelic data collection, like OPEN and RMPDS, to compare outcomes and finally build a more holistic view of psychedelic use and outcomes.
Help us build the most comprehensive, holistic view of naturalistic psychedelic use ever created.
Inside the IRIS Registry, We’ll Measure:
Context and Preparation
Baseline data on motivations, intentions, social support, and preparation before the experience.
Experience and Outcomes
Tracking of mental health (PHQ-9, GAD-7), well-being (WEMWBS-7), subjective experience, and adverse events up to 12 months.
Social and Relational Dynamics
Instruments focused on peer integration, group-trip dynamics, and the influence of family/social systems.
Integration and Functional Change
Measurement of integration practices (IES & EIS) and functional outcomes at 1, 3, and 12 months post-experience.
Project IRIS is Groundbreaking and Crucial
With meticulous design and a 12-month follow-up window, IRIS will bridge emerging clinical science with the reality of naturalistic use, ensuring policymakers and the public are armed with facts, not fear.
The IRIS Registry is a crucial, high-impact project. We need both participants to generate the data and funding to ensure a successful launch in 2026. How do you want to accelerate the research?
- Social Dynamics of Group Use: We are the only registry exploring how group experiences, preparation rituals, and peer-led integration shape outcomes.
- Longitudinal Outcome Tracking: We track participants over time (1-week, 1-month, 3-months, 12-months) to understand long-term integration and change.
- NFU Context Matters: Unlike broad prevalence surveys, we focus on the depth of set, setting, and context unique to non-facilitated experiences.
- Alignment is Power: Using validated measures from OPEN, we ensure our data is comparable with facilitated use, creating the largest, most robust dataset possible.
The IRIS Registry is a crucial, high-impact project. We need both participants to generate the data and funding to ensure a successful launch in 2026. How do you want to accelerate the research?
Join the Waitlist
Join the waitlist to be notified as soon as recruitment begins for the baseline launch. We seek adults over 21 globally who have engaged in intentional, non-facilitated psychedelic use (excludes microdosing).
- Empower Yourself with Your Own Data: Participants will have access to their personal long-term outcome data (up to 12 months).
- Advance Public Health Policy: Your experience helps provide robust data to inform public policy and regulatory bodies.
- Contribute to the First Holistic View: Be part of the first large-scale effort to compare outcomes in facilitated and non-facilitated use.
- Help Design Future Research: Your data will directly inform the scientific community on safety, integration, and group dynamics.
- Sync Wearable Data (Future Potential): Phase 2 may allow for syncing biometric health data from wearable tech (like Apple Watch or Oura Ring) to add depth to your outcomes. you'll be among the first notified if this feature is integrated.
Fund the Project
Your financial support is critical to covering the essential platform build, IRB approval, and instrument selection phase. Help us secure the $250,000 in seed funding needed for a successful 2026 launch.
- Secure Foundational Data: Directly unlock the initial 6-month build and enable the study launch for non-facilitated psychedelic use.
- Influence Policy at Scale: Fund the data that policymakers critically need to make informed decisions about regulation and public health.
- Catalyze Collaborative Synergy: Your support enables a unique collaboration, creating resources that align data with industry-leading studies.
- Gain Priority Access: Receive exclusive updates, early access to interim data reviews, and invitations to scientific collaborator discussions.