ABSTRACT Objective: Suicide is a global health concern, and innovative interventions that target suicidality are needed. While psychedelic therapy shows promise for a range of
ABSTRACT Background: Psilocybin therapy has shown promise as a rapid-acting treatment for depression, anxiety, and demoralization in patients with serious medical illness (e.g., cancer)
IMPORTANCE Bipolar II disorder (BDII) is a debilitating condition frequently associated with difficult-to-treat depressive episodes. Psilocybin has evidence for rapid-acting antidepressant effects but has not
Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in
Abstract What happens when an emerging programme of medical research overlaps with a surging social movement? In this article we draw on the anthropological
ABSTRACT Objective: To systematically review control conditions of all available randomized psychedelic trials. Data Sources: We searched PubMed, PsycINFO, and EMBASE for randomized trials of
Abstract Background: The classical psychedelics, psilocybin, peyote, ayahuasca/N,N-dimethyltryptamine, and lysergic acid diethylamide are considered promising new treatments for psychiatric illnesses, such as depression, anxiety,
Background: Psilocybin may help treat obsessive–compulsive disorder (OCD). To date, only one open-label study of psilocybin for OCD exists, necessitating further investigation with a randomized
ABSTRACT New medicines containing classic hallucinogenic and entactogenic psychedelic substance are under development for various psychiatric and neurological disorders. Many of these, including psilocybin,
Abstract Background: In the past few years, the issue of ‘microdosing’ psychedelics has been openly discussed in the public arena where claims have been
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