Can psilocybin treat addiction?

Recent research suggests that psilocybin shows promise in treating addiction. Studies have demonstrated its potential efficacy in treating tobacco and alcohol dependence, with high abstinence rates reported at follow-up (Garcia-Romeu et al., 2015; Johnson et al., 2014; Bogenschutz et al., 2015). Psilocybin-occasioned mystical experiences appear to play a crucial role in the treatment process, correlating with positive outcomes (Garcia-Romeu et al., 2015; Bogenschutz et al., 2018). The substance has a low risk of toxicity and dependence, making it potentially safe for clinical use under controlled conditions (de Veen et al., 2017; Ziff et al., 2022). Psilocybin’s mechanism of action involves 5-HT2A receptor agonism, which may contribute to its therapeutic effects (Johnson, 2022). While results are promising, researchers emphasize the need for larger, well-designed placebo-controlled trials to confirm efficacy (de Veen et al., 2017; Miranda et al., 2021). Overall, psilocybin shows potential as a novel treatment option for substance use disorders, warranting further investigation.