Are magic mushrooms safe to use?

Psilocybin is relatively safe to use with minimal known long term adverse reactions. In our large-scale study of psilocybin use enrolling over 8,000 individuals, adverse reactions were rare, with less than 1% of participants reporting seeking medical care, and less than 4% seeking psychological care. However, psilocybin is not without risk.  A minority of participants in our study (11% at 2-4 weeks and 7% at 2-3 months follow up) reported persisting negative effects after psilocybin use (e.g., mood fluctuations, depressive symptoms). The most commonly reported persisting negative effects after psilocybin use were mood fluctuations (n = 55; 4.7% at 2-4 weeks, and n = 20; 3.0% at 2-3 months) and depressive notions (n = 37; 3.1% at 2-4 weeks, and n = 11; 1.7% at 2-3 months).

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