Psilocybin is relatively safe to use with minimal known long term adverse reactions. In our large-scale study of psilocybin use enrolling over 8,000 individuals, adverse reactions were rare, with less than 1% of participants reporting seeking medical care, and less than 4% seeking psychological care. However, psilocybin is not without risk.  A minority of participants in our study (11% at 2-4 weeks and 7% at 2-3 months follow up) reported persisting negative effects after psilocybin use (e.g., mood fluctuations, depressive symptoms). The most commonly reported persisting negative effects after psilocybin use were mood fluctuations (n = 55; 4.7% at 2-4 weeks, and n = 20; 3.0% at 2-3 months) and depressive notions (n = 37; 3.1% at 2-4 weeks, and n = 11; 1.7% at 2-3 months).

Always seek the advice of your physician or other qualified health care provider before undertaking a new health care regime. Unlimited Sciences does not give or substitute for medical advice. The products and services discussed are not intended to diagnose, cure, prevent or treat any disease. Please click here to read our full disclaimer.