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Explore our growing library of studies, reports, and publications. Each piece of psychedelic science is designed to inform practitioners, participants, policymakers and curious minds alike.
Our comprehensive collection of peer-reviewed psychedelic research features impactful studies on a wide range of conditions and psychedelic substances.
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The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction
Abstract Mescaline, among the earliest identified natural hallucinogens, holds great potential in psychotherapy treatment. Nonetheless, despite the existence of a postulated biosynthetic pathway for more than half a century, the specific enzymes involved in this process are yet to be identified. In this study, we investigated the cactus Lophophora williamsii (Peyote), the largest known natural […]
August 9, 2024
Psilocybin‑assisted therapy and HIV‑related shame
Abstract As a proposed mediator between stigma-related stressors and negative mental health outcomes, HIV-related shame has been predictive of increased rates of substance use and difficulties adhering to antiretroviral treatment among people with HIV. These downstream manifestations have ultimately impeded progress toward national goals to End the HIV Epidemic, in part due to limited success […]
August 8, 2024
Psychedelic‑assisted psychotherapy: where is the psychotherapy research?
Rationale Psychedelic-assisted psychotherapy (PAP) has emerged as a potential treatment for a variety of mental health conditions, including substance use disorders and depression. Current models of PAP emphasize the importance of psychotherapeutic support before, during, and after ingestion of a psychedelic to maximize safety and clinical beneft. Despite this ubiquitous assumption, there has been surprisingly […]
July 18, 2024
How Do Psychedelics Reduce Fear of Death?
Abstract Increasing evidence suggests that psychedelic experiences, undergone in controlled conditions, can have various durable psychological benefits. One such benefit is reductions in fear of death, which have been attested in both psychiatric patients and healthy people. This paper addresses the question: how, exactly, do psychedelic experiences reduce fear of death? It argues, against some […]
June 19, 2024
Considering the nocebo effect in the psychedelic discourse
Abstract This commentary addresses the potential for a nocebo effect arising from the public discourse on psychedelics, especially considering the increasing interest and engagement with these substances. The resurgence of psychedelics in the public and scientific arenas has led to a proliferation of discussions, both positive and cautionary, about their use. However, an imbalance in […]
June 18, 2024
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