When taking classic psychedelics such as psilocybin—the main psychoactive substance contained in many species of hallucinogenic mushrooms—sleep can be impacted negatively by disrupting sleep patterns in the hours following ingestion. Psilocybin, or magic mushrooms, can disrupt short-term sleep quality by prolonging the onset of REM sleep in the hours following ingestion and promoting alertness and wakefulness. While it is possible to fall asleep while under the influence of magic mushrooms, it may be more challenging than usual. Anecdotal reports from users of psilocybin frequently describe difficulties falling and staying asleep immediately after taking hallucinogenic mushrooms, but sleep typically returns to normal once the effects of psilocybin subside. The effects of psilocybin typically last for 4 to 6 hours, but some individuals report residual or lingering effects past this time period. After 6 to 8 hours most traces of psilocybin are no longer detectable in the body.
While psilocybin is a relatively safe substance that has been found to have minimal harmful effects, based on the available evidence, it is not recommended to take psilocybin-containing mushrooms immediately prior to sleeping. Psilocybin can make you more alert in the hours following ingestion, making it difficult to fall asleep.
Research has not found that psilocybin has negative, long-term implications on sleep.
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