Regarding eyes-open versus eyes-covered, while psychedelic-induced visual effects can occur with eyes-open or eyes-closed, visual alterations under classic psychedelics can include rich phenomenological accounts of eyes-closed imagery (Stoliker et al., 2022). In fact, a recent investigation of neuronal oscillations for psilocybin-induced spiritual experiences, suggested that compared with eyes-open, eyes-closed conditions involved additional neuronal network processes associated with insightfulness and spiritual experiences (Kometer et al., 2015).

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