If you’re wondering how to enroll in a clinical trial using psilocybin, the first step is finding reputable, up‑to‑date information. The best place to start is ClinicalTrials.gov. This blog explains what clinical trials are, how to search for psilocybin trials, what you may find, and how to prepare for participation, all backed by reliable sources.
ClinicalTrials.gov is the official registry of clinical research.
Run by the National Library of Medicine at NIH, ClinicalTrials.gov holds registrations for over 546,000 trials from all 50 US states and 229 countries and territories This vast database ensures you’re looking at legitimate, regulated studies.
Here’s how to search for psilocybin clinical trials:
Go to ClinicalTrials.gov and enter “psilocybin” in the search bar. Then filter by “Recruiting” status and location “United States.” This will show you the latest trials you may be eligible for. Each trial page includes:
- The purpose of the trial (such as depression, PTSD, end‑of‑life anxiety)
- Eligibility criteria (age range, health status, diagnoses)
- Locations and contact info (sites across the U.S.)
- Whether the study is interventional or observational
- Key dates (start and estimated completion)
Why is psilocybin is being studied?
Psilocybin is under investigation for potential mental health benefits, including treatment for depression, PTSD, substance use disorders, and anxiety. These studies are scientifically controlled and conducted by academic medical centers and licensed researchers.
- Carefully read the inclusion/exclusion criteria
- Review the protocol’s description and location
- If eligible, contact the study coordinators directly via email or phone
- If not eligible, keep checking—new trials open frequently
What to expect if you enroll.
Psilocybin clinical trials typically involve multiple visits, including intake screening, baseline assessments, dosing sessions in a controlled setting, follow‑up assessments, and sometimes integration sessions to process the experience. Before you apply:
- Confirm Institutional Review Board (IRB) approval for safety protocols
- Ask about the type of psilocybin (synthetic or extracted), dosage, and session frequency
- Clarify compensation (some trials reimburse travel or offer stipends)
- Prepare for screening questionnaires and medical assessments
- Understand the difference between clinical support and recreational use. These are therapeutic protocols, not retreats
ClinicalTrials.gov is the most current and comprehensive listing of U.S. trials. Recruitment status is accurate and updated, and you’ll connect directly with official coordinators, without third‑party paywalls.
Checking every few weeks helps you catch newly opened trials or additional locations.
Enrolling in a psilocybin clinical trial is a transparent, carefully monitored way to participate in cutting‑edge mental health research.
If you’re looking for personalized guidance and support before or after a psychedelic experience, the Unlimited Sciences Psychedelic Info Line offers free, 1:1 support for answering questions about psychedelic safety, integration, and emotional processing.