Results from our recent large-scale study with Johns Hopkins University found significantly decreased depression persisting for months following psilocybin ingestion. For individuals who have treatment-resistant depression, which means they haven’t responded to traditional treatments for depression, psilocybin may be a safe and effective treatment. While many individuals respond well to traditional methods of treating depression, such as psychotherapy or antidepressants, these strategies sometimes fail. Treatment-resistant depression is a subset of Major Depressive Disorder affecting one in three diagnosed patients. Recent evidence suggests that psilocybin works differently from conventional antidepressants, such as serotonin reuptake inhibitors (SSRIs). Psilocybin could be a promising alternative approach to depression treatments.

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