Yes, research suggests that psilocybin may offer significant relief for people with treatment-resistant depression and major depressive disorder. In clinical studies, just two doses of psilocybin in a supportive setting led to rapid improvements that lasted 3 to 6 months (study).
In comparisons with SSRIs like escitalopram, psilocybin performed equally or better on several measures, especially in emotional well-being (trial). It has also shown potential benefits even when used by individuals currently on antidepressants, though combining the two can increase the risk of serotonin syndrome — a rare but serious condition (study, overview).
In a large-scale real-world survey by Unlimited Sciences, users reported a drop in depression symptoms from 42% to 14.5% within 2–3 months (results).
However, psilocybin isn’t risk-free. Some individuals report anxiety, emotional sensitivity, or physical effects like nausea and headaches. It may worsen symptoms in people with bipolar disorder or psychosis, and careful screening and support are essential (safety review).
While more research is needed, psilocybin shows strong potential as a therapeutic tool for depression — especially when used with professional guidance.
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